What if some of the biggest gains in patient safety aren’t inside hospitals at all—but at the kitchen table?
In this episode, Dr. Amy Billett and Dr. Chris Wong walk us through the groundbreaking, cross-disciplinary effort at Dana-Farber/Boston Children’s in collaboration with Ariadne Labs that cut ambulatory central-line–associated bloodstream infections (CLABSIs) for pediatric oncology patients by ~50%.
It’s a story of co-design, equity, humility, and design thinking—with families as full collaborators, not passive recipients.
Instead of pushing out top-down fixes, the team built the work with families, home-care nurses, and even a checklist engineer who transformed dense clinical instructions into clear, waterproof (yes, literally waterproof), one-page cognitive aids that could survive kitchens, bathrooms, and real homes. They aligned inpatient teaching with home supplies, created universal clean kits to eliminate equity gaps, rebuilt teach-backs to remove shame, and translated materials into Spanish and Arabic so safety didn’t depend on luck or language.
You’ll also hear how Amy’s three-decade career in pediatric quality and safety shaped the work—and how her mentorship of Chris helped fuel the next generation of system thinkers committed to closing the “know-do gap” in medicine.
At a time when more care is shifting homeward, this episode offers a playbook for making safety real beyond the hospital walls.
What We Cover
The overlooked problem: Ambulatory CLABSIs after discharge and their impact on hospitalizations, chemotherapy delays, and family burden.
Why usual fixes failed: Families were doing complex care with inconsistent, hard-to-use instructions not designed for home environments.
Co-design in action: Families, clinicians, home-care nurses, and a checklist engineer created standardized, waterproof, one-page cognitive aids and aligned teaching with real home supplies.
Human-factors design: The checklist engineer brought clarity, usability, and visual design clinicians alone couldn’t achieve.
A new model for teachbacks: Judgment-free, normalized teachbacks led by nurse champions—resulting in >90% caregiver independence.
Equity at the center: Universal clean kits and multilingual materials ensured safe care didn’t depend on resources or language.
Leadership & mentorship: How Amy’s decades in pediatric safety and Chris’s drive to close the know-do gap shaped the work.
Ripple effects: National collaboratives adopting ambulatory CLABSI prevention and emerging focus on home medication safety.
Key Takeaways
Safety challenges often live beyond the hospital.
Co-design works—families reveal solutions clinicians cannot see alone.
Usability matters: Clear language and well-designed tools drive real behavior change.
Equity requires universal design, not selective support.
Connect with Today’s Guests
Dr. Amy Billett
Best contact method: https://www.linkedin.com/in/amy-billett-a351501a6/
Dr. Chris Wong
Best contact method: https://www.linkedin.com/in/chris-i-wong-ciepiel-884880145/
Profile Link: https://www.uhhospitals.org/doctors/WongCiepiel-Chris-1407171804
Leading Quality is a podcast for healthcare leaders committed to improving systems, culture, and outcomes.
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Credits:
Host, Writer, and Executive Producer
Jason Meadows, MD
Produced by
Thrive Healthcare Improvement
Edited by
Milan Milosavljevic
